Any airport that receives international flights can be a POE and should be equipped with appropriate immigration facilities.
One thing to bear in mind, though, is that a lot of Cleveland's international flights come from cities that have US pre-clearance. For example, in Dublin, you go through US customs and border control at the Dublin airport, so technically Dublin is an American POE. The same is true of Toronto. So when you're scheduling your flights, that's something to keep in mind - do your research on any connecting flights you may need to take, as you'll want to have ample layover time if that's the case for you!
Edit: I just did a quick look at Google flights and there are no direct flights that I can see from Manila to Cleveland. Likely, you'll connect in a different US city that will serve as your port of entry. Again, if that's the case, make sure you have ample layover time!