My son's F was also working in the US when the couple met, so she has SSN and prior work visa - that hasn't come up as an issue at all. They both lived and worked in Italy after her job here ended, had a beautiful baby boy, and decided to return to the US when the economy in Italy hit the Covid wall. Had we known how long the process would be, they would have either married in Italy or had him stay there until the Visa was ready.
For visiting - fortunately, Italy does not raise a lot of eyebrows, and the family has been able to visit and stay connected through this very long process. The impact has been on her ability to work in Italy - they aren't fond of temporary or gig work.
Wishing your family the very best luck on your journey!