The CO is under DOS, not USCIS. DOS CO's are not always well-versed in policies regarding adjustment of status, same way that USCIS IO's are not always aware of visa processing regulations. In your wife's case, USCIS will determine if she is eligible for AOS. Here's a better source from the USCIS policy manual -- https://www.uscis.gov/policy-manual/volume-7-part-b-chapter-2
Urgent Humanitarian Reasons or Significant Public Benefit
DHS may parole a noncitizen based on urgent humanitarian or significant public benefit reasons.[42] DHS may grant urgent humanitarian or significant public benefit parole only on a case-by-case basis.[43] Any type of urgent humanitarian, significant public benefit, or deferred inspection-directed parole meets the “paroled into the United States” requirement.[44]