As of May 26, 2022:
Frequently Asked Questions New Relief Options for Ukrainians.pdf
"Q: Can someone who is paroled under U4U travel abroad, either with advance parole or an existing B1/B2 visa?
A: USCIS notes on its U4U website that if someone has already been paroled into the United States, their parole will automatically be terminated if the individual departs without obtaining advance authorization to travel. However, neither DHS nor USCIS has clarified whether someone paroled in under U4U is even eligible for advance parole. Note that a parolee who departs and then attempts to re-enter the United States using a B1/B2 visa may terminate his or her parolee status upon admission in B1/B2 status. The parolee may also face scrutiny at the port of entry regarding whether they possess the requisite nonimmigrant intent. Until there is more clarity on this issue and guidance from DHS, U4U beneficiaries should be cautioned about traveling abroad."