Hi,
Once your status changes to READY at https://ceac.state.gov, you can complete the DS-160, create your profile with your Embassy and pay the Visa fee.
Check this website for your country as to how to create the profile - someone posted it before - https://www.ustraveldocs.com/.
For Dominican Republic Embassy, I needed to complete the DS-160 before creating the profile.
Check the requirements for your Embassy.
Once I submitted the DS-160, created the profile and paid the fee, I sent an inquiry to the Embassy letting them know I did all that.
They said I will get an email reply once they review it so that I can go into the profile again and get access to the interview calendar.
I now have to wait for them to let me see the interview calendar to pick the date.
I paid on Dec 14th and still haven't heard anything so still waiting🙏🤞. This is where it can take a few weeks, at least for Dominican Republic, your Embassy might be faster.