CDC quietly deletes hydroxychloroquine guidance as study hyped by Trump comes into question

[Steeleballz 7,550]

4 minutes ago, Voice of Reason said:

What are your medical credentials?  MD/DO/PA/LPN?

 

I would do ANYTHING to safe my life if I was in a hospital and dying from covid or any other virus.  As would anyone with a working brain cell, unless they were just tired of living.

 

   I already told you what treatments I would want. Antivirals and convalescent plasma. You can (and should) do whatever you think works. I'm not telling you what I think you should do, and I'm not sure why you are so concerned with what I would do. I've told you several times now that I probably would not take HCQ. Just accept it. I'm not going to drink bleach or rinse my nose with rubbing alcohol either in case you are curious.

[OriZ 3,157]

1 hour ago, Voice of Reason said:

Waffler.  Of COURSE you'd take it.  You'd do ANYTHING to save your skin.  Just admit it.

 

Also, skip the plasma treatment.  Go for a full-on blood transfusion.  O+, preferably.

Speaking of which, anyone hear of this?

 

https://www.sciencealert.com/paper-suggests-certain-blood-types-might-be-slightly-more-susceptible-to-covid-19

 

I happen to be O positive...wouldn't mind if it was true

[OriZ 3,157]

1 hour ago, TBoneTX said:

Some time ago, he offered to ship the caravans of illegals to them, and the mayors shut up in a hurry.

Hmmm...interesting tactic, maybe he can endorse Biden too.

[Steeleballz 7,550]

22 minutes ago, OriZ said:

Speaking of which, anyone hear of this?

 

https://www.sciencealert.com/paper-suggests-certain-blood-types-might-be-slightly-more-susceptible-to-covid-19

 

I happen to be O positive...wouldn't mind if it was true

 

 

   They have noticed the same tendency with other Coronaviruses, and also with SARS, although with a much smaller sample size. It's interesting, because there are plausible mechanisms for how blood group systems and immunity are interrelated. I'm also O pos, but I don't think it's statistically significant enough to where we don't have to worry about it, but like some of the other things, maybe there's a slight benefit.

 

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475644/#!po=4.28416

[OriZ 3,157]

6 hours ago, Steeleballz said:

 

 

   They have noticed the same tendency with other Coronaviruses, and also with SARS, although with a much smaller sample size. It's interesting, because there are plausible mechanisms for how blood group systems and immunity are interrelated. I'm also O pos, but I don't think it's statistically significant enough to where we don't have to worry about it, but like some of the other things, maybe there's a slight benefit.

 

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475644/#!po=4.28416

That link doesn't seem to be working for me.

 

Yeah, I mean, it's not like the differences are huge, but hey, we'll take what advantage we can get.

[Steeleballz 7,550]

1 hour ago, OriZ said:

That link doesn't seem to be working for me.

 

Yeah, I mean, it's not like the differences are huge, but hey, we'll take what advantage we can get.

 

   Oops. Maybe it's something I'm subscribed too. Here's the excerpt from the article about SARS.

  

SARS and ABO

Severe acute respiratory syndrome (SARS) is caused by the SARS coronavirus (SARS-CoV), an RNA virus. The original SARS outbreak in the winter of 2002 to 2003 infected >8,000 individuals worldwide, with a fatality rate of 10% (292). Like other human coronaviruses, SARS-CoV infects the mucosal epithelium, causing an acute respiratory illness often accompanied by gastroenteritis. In a Hong Kong outbreak, there was an apparent association between disease transmission and ABO type (293). An epidemiology study of 34/45 hospital workers who contracted SARS after exposure to a single index patient showed that most of the infected individuals (23/34) were non-group O individuals (groups A, B, and AB). Group O individuals were relatively resistant to infection, with an OR of 0.18 (95% CI, 0.04 to 0.81; P = 0.03).

Like HIV, coronavirus is an enveloped virus that targets host cells via a viral adhesion glycoprotein. The SARS-CoV spike (S) protein is a 210- to 230-kDa glycoprotein with 23 potential N-glycosylation sites (292). Glycan analysis shows a wide range of structures, including complex N-glycans with 2 to 4 antennae capable of supporting ABH epitopes (292, 294). Because the virus targets respiratory and gastrointestinal mucosa, it is highly likely that most human isolates express ABH antigens on the S protein and host envelope GSLs. Like the Env protein, S protein expressing A antigen can be blocked by monoclonal anti-A and human anti-A (292).

[yuna628 9,713]

Remember I said COVID is causing people to have extreme clotting? Here's a doctor trying this experimental treatment.

 

https://abcnews.go.com/Health/wireStory/doctor-gambles-clot-busting-drug-save-virus-patients-70100830

[OriZ 3,157]

1 hour ago, Steeleballz said:

 

   Oops. Maybe it's something I'm subscribed too. Here's the excerpt from the article about SARS.

  

SARS and ABO

Severe acute respiratory syndrome (SARS) is caused by the SARS coronavirus (SARS-CoV), an RNA virus. The original SARS outbreak in the winter of 2002 to 2003 infected >8,000 individuals worldwide, with a fatality rate of 10% (292). Like other human coronaviruses, SARS-CoV infects the mucosal epithelium, causing an acute respiratory illness often accompanied by gastroenteritis. In a Hong Kong outbreak, there was an apparent association between disease transmission and ABO type (293). An epidemiology study of 34/45 hospital workers who contracted SARS after exposure to a single index patient showed that most of the infected individuals (23/34) were non-group O individuals (groups A, B, and AB). Group O individuals were relatively resistant to infection, with an OR of 0.18 (95% CI, 0.04 to 0.81; P = 0.03).

Like HIV, coronavirus is an enveloped virus that targets host cells via a viral adhesion glycoprotein. The SARS-CoV spike (S) protein is a 210- to 230-kDa glycoprotein with 23 potential N-glycosylation sites (292). Glycan analysis shows a wide range of structures, including complex N-glycans with 2 to 4 antennae capable of supporting ABH epitopes (292, 294). Because the virus targets respiratory and gastrointestinal mucosa, it is highly likely that most human isolates express ABH antigens on the S protein and host envelope GSLs. Like the Env protein, S protein expressing A antigen can be blocked by monoclonal anti-A and human anti-A (292).

Interesting...I'm wondering if it's not necessarily that people with this blood type are infected in lower numbers per se, but maybe they don't develop severe symptoms very often and are thus missed more? I wish they would do a study of deaths based on blood type, I think it would tell us more

[Steeleballz 7,550]

1 hour ago, yuna628 said:

Remember I said COVID is causing people to have extreme clotting? Here's a doctor trying this experimental treatment.

 

https://abcnews.go.com/Health/wireStory/doctor-gambles-clot-busting-drug-save-virus-patients-70100830

 

    I've been following the tPA study here that Dr Moore is doing. They have had some preliminary success. Right now they are only allowed to do a compassionate use trial, which means the people have exhausted other treatment options. They are hoping to get FDA approval to do an actual clinical trial.

[Steeleballz 7,550]

36 minutes ago, OriZ said:

Interesting...I'm wondering if it's not necessarily that people with this blood type are infected in lower numbers per se, but maybe they don't develop severe symptoms very often and are thus missed more? I wish they would do a study of deaths based on blood type, I think it would tell us more

 

  I think it's both. If the anti-A is neutralizing the viral receptor, depending on the persons anti-A titre, there could be enough to neutralize all of the virus, or just some of it. So some people may not get infected at all, and others would get infected with lower numbers which would still give the immune system an advantage relative to someone without anti-A. 

 

  They also said in the research that there is another gene involved that controls whether antibody ends up in mucosal areas like the respiratory tract or the gut. About 80% of people have that gene, but varying significantly by ethnic groups, so ~20% of group O people in the overall population would not have any protection. Explains why some group O people still get severe symptoms. 

[TBoneTX 46,124]

12 hours ago, Voice of Reason said:

You've made it clear you are in the medical profession just wanting to make sure it's not podiatry or orthopedics if you're offering viral advice.

Kindly suggested:  it's reasonable to trust that he's qualified to comment.

[Nature Boy 2.0 8,382]

4 hours ago, TBoneTX said:

Kindly suggested:  it's reasonable to trust that he's qualified to comment.

You reminded me of the auto expert on my Cousin Vinny. Lol

 

Maybe Steelz is a pediatric resident 😃

 

I do agree he seems to be very knowledgeable and rational. 

 

On edit...on this subject 

Edited April 11, 2020 by Nature Boy 2.0

[Dashinka 24,798]

Experimental coronavirus drug remdesivir is showing early promise, research says
 

https://www.foxnews.com/science/experimental-coronavirus-drug-remdesivir-is-showing-early-promise-research

[Nature Boy 2.0 8,382]

1 minute ago, Dashinka said:

Experimental coronavirus drug remdesivir is showing early promise, research says
 

https://www.foxnews.com/science/experimental-coronavirus-drug-remdesivir-is-showing-early-promise-research

Dont dare let Trump repeat that 

[Steeleballz 7,550]

10 minutes ago, Nature Boy 2.0 said:

Dont dare let Trump repeat that 

 

   He probably should talk about it. This is one of the treatments that worked from day 1. Worked well against SARS and MERS too and several other viruses. We also know what it does and why it works. It is designed specifically to stop RNA viruses from replicating. Still works better if you take it earlier in the infection. The big question now is will it be approved for use before the damn pandemic is over.