genes for caffeine consumption found

[Amby 490]

Whether or not you're a caffeine junkie is in part determined by your genes, a new study says.

The study identified two genes associated with the amount of caffeine people consume. Both of the genes are known to be involved in the breakdown of caffeine in the liver.

The findings suggest one of the main reasons why some people drink more caffeine than others is that the heavy drinkers are better able to tolerate it, the researchers say. The study did not find a strong link between caffeine consumption and genes involved in the brain's response to caffeine.

While both the liver and the brain influence caffeine consumption, "It turns out that your liver, more than your brain, determines daily caffeine intake," said study researcher Neil Caporaso, of the National Cancer Institute.

"You might think, I drink caffeine to feel good, or not to feel bad, but that, in turn, is established by how fast your liver breaks down the caffeine," Caporaso said. "If your liver breaks it down very rapidly, then likely you drink more."

More than 90 percent of U.S. adults consume caffeine, and the findings provide insight into what influences this habit, which can be good or bad. In moderation, caffeine might counter cognitive decline, but too much can impair cognition, cut into sleep and even cause hallucinations.

Genes for caffeine

Studies on twins have suggested that the amount of caffeine a person drinks is, in part, hereditary. But researchers didn't know what genes determine this caffeine preference.

Caporaso and his colleagues scanned the genes of more than 47,000 individuals. Participants answered questions about how much coffee, tea, soda and chocolate they consumed.

The researchers identified two genes, CYP1A2 and AHR, that are associated with caffeine intake. Everybody has these genes, but some people have variations that are more active than others. People with the most active versions of these genes drank about 40 milligrams more of caffeine than did people with the least active version, Caporaso said. That's equivalent to an 8-ounce can of Diet Coke, Caporaso said.

Both CYP1A2 and AHR have been previously identified as genes that break down caffeine. But researchers didn't know that having a different version of these genes would influence how much caffeine people drink, Caporaso said.

The method used to find these genes, known as a genome-wide association study, looks for genes linked to a disease or habit in a completely unbiased manner. This means the researchers went into the study without a preconceived idea of what they were going to find.

Future work

The gene CYP1A2 is involved in the breakdown of many chemicals, including carcinogens. Caporaso would like to see whether variations of this gene also influence a person's cancer risk, he said.

The researchers are also investigating whether people who don't drink any caffeine at all have special genetic variations, Caporaso said.

The study is published in the journal PLoS Genetics.

http://www.livescience.com/13600-caffeine-genes.html

[Zero Sum 305]

What about the gene that makes you get the runs after drinking coffee? I bet that upsets some people out there.

[Amby 490]

What about the gene that makes you get the runs after drinking coffee? I bet that upsets some people out there.

caffeine stimulates peristalsis in the gastrointestinal system and colon. because of this it makes stuff move through faster.

[Zero Sum 305]

caffeine stimulates peristalsis in the gastrointestinal system and colon. because of this it makes stuff move through faster.

There has to be some gene for that.

[Amby 490]

There has to be some gene for that.

a gene for a stimulant stimulating?

[Zero Sum 305]

a gene for a stimulant stimulating?

No a gene for caffeine hyperstimulation of gastric emptying! You've never seen anyone sipping some French roast and then running 30 minutes later to the john?

[Amby 490]

No a gene for caffeine hyperstimulation of gastric emptying! You've never seen anyone sipping some French roast and then running 30 minutes later to the john?

I've never witnessed that but I'm sure it happens. You should study it!

[Obama 2012 1,714]

interesting enough, but i'd also be curious of how many in the study group did and/or did not have the addictive genes...

[Zero Sum 305]

I've never witnessed that but I'm sure it happens. You should study it!

"I'm immune to caffeine"

[Dan and Judy 614]

caffeine stimulates peristalsis in the gastrointestinal system and colon. because of this it makes stuff move through faster.

gastrointestinal system and colon?

[Amby 490]

gastrointestinal system and colon?

what's the question?

[Dan and Judy 614]

Whether or not you're a caffeine junkie is in part determined by your genes, a new study says.

Genes for caffeine

The researchers identified two genes, CYP1A2 and AHR, that are associated with caffeine intake. Everybody has these genes, but some people have variations that are more active than others. People with the most active versions of these genes drank about 40 milligrams more of caffeine than did people with the least active version, Caporaso said. That's equivalent to an 8-ounce can of Diet Coke, Caporaso said.

Both CYP1A2 and AHR have been previously identified as genes that break down caffeine. But researchers didn't know that having a different version of these genes would influence how much caffeine people drink, Caporaso said.

http://www.livescien...eine-genes.html

My colleagues and I determined that the sipia2 and the AHR are relatively insignificant in the consumption caffeine. The biggulpia3 and the Ampability genes have a much more profound influence and I'm not talking about an 8 .oz soda.

We performed a double blind study, both the researchers and the subjects were blindfolded. This was not a fly by night operation inspite of the great quantities of caffeine consumed. This study was conducted in one of the largest malls in the entire nation.

We tricked the subjects into thinking it was a blind taste test. Coke vs pepsi.

We measured the relevant genes of all the volunteers using the latest scientific methods. In keeping with ethical mandates we wore the blindfolds while measuring the ladies. After scrupulously measuring and recording that data we blindfolded the subjects and

told them to taste the soda. we did not tell them how much to drink or when to stop.

The amount of soda consumed was directly proportional to the size of the biggulpia3 and the ampability genes. the biggulpia influence was roughly 30% greater. The women with a mutagenic expression of the biggulpia3 that we called a protuberance, drank

a full 64 oz. of soda before they offered their conclusions. The statistical probability of a variance utilizing a 3rd degree regression analysis, calculated in relation to chi-squared was .007. We felt that was quite ironic since James Bond felt that tea was largely

responsible for the decline of the British empire.

[Dan and Judy 614]

what's the question?

Isn't the colon part of the gastrointestinal system

Edited April 8, 2011 by Dan and Judy

[Amby 490]

Isn't the colon part of the gastrointestinal system

yeah but I put it like that because the stimulation ends at the colon. it doesn't stimulate your #######.

[Dan and Judy 614]

yeah but I put it like that because the stimulation ends at the colon. it doesn't stimulate your #######.

Don't worry a redundant colon is rarely fatal. In regards to stimulating the ####### pepsi has a solution for that.