How can I get this science article?

[IR5FORMUMSIE 850]

Just checked. We do NOT have it on our library subscription registry. Sorry.

My accounts are down but I don't think that I've ever heard of that publication. It is more in the realm of radiation oncology and those guyz iz nucking futs. I'm not too up on heat shock protein remodeling, I thought that it was primarily the quaternary structures of the hsp that change or do the tertiary structures also change and this causes the quaternary structure to also change. Sorry, I'm tired I can't think stright right now and I haven't looked at this stuff in a while.

I wonder if this makes anyone else think about the safety of cell phones.

Edited November 21, 2009 by IR5FORMUMSIE

[HAL 9000 96]

Just checked. We do NOT have it on our library subscription registry. Sorry.

My accounts are down but I don't think that I've ever heard of that publication. It is more in the realm of radiation oncology and those guyz iz nucking futs. I'm not too up on heat shock protein remodeling, I thought that it was primarily the quaternary structures of the hsp that change or do the tertiary structures also change and this causes the quaternary structure to also change. Sorry, I'm tired I can't think stright right now and I haven't looked at this stuff in a while.

I wonder if this makes anyone else think about the safety of cell phones.

Maximum stimulus detected! LOL

Not sure about the journal. If they had published in Wiley's publishing group or at least a journal that Pubmed Central could mirror for free then hey... we'd likely not have this thread.

So I actually was at a mitochondrion talk last week that showed some awesome Hsp60 staining at the cell level. It was a cancer talk, but it dealt more with metabolic changes in a tumor line after knocking out another gene.

So as to the Hsp's themselves- most of them stay in quaternary formation (unless you're dealing with a cellular disorder that actually denatures them down in level to 3ry or *gasp* lower) because they tend to respect subcellular compartmentalization really strictly. Hence why you have mitochondrial Hsp's and cytosolic ones. Obviously once something like Hsp60 is translated its targeted to mitochondria since it may have once been in the mitochondrial genome... but that changed with evolution. So it had to travel back to the mitochondrion. Once membrane translocation occurs into the mitochondrial matrix then it resumes its mature 4ry structure.

I guess the entire point of heat therapy at certain stages of mitochondrial dysfunction would involve activating these Hsp60s to target heat-affected proteins (da daaa... usually those that are already damaged or associated with reactive oxygen species) for degradatory measures without having the entire mitochondrion lose its membrane potential and thusly, caspase activation.

I wonder though what kind of feasable strategy a therapist could use to heat the brain to such a point where, say, a striatal tumor could be attacked via such a route without overactivating other Hsp proteins to push entire cells... too far. Its not like most neurons can revert back to pre-cell cycle arrest.

[Niels Bohr 72]

Electromagnetic Fields is the specialty of physicist and electrical engineers. Don't know if in medicine you guys study EMF fields, energy distribution, propagation, Laplace, Gaussian, vectors analysis.

Cell phone radiation can't possibly interact with the protein structures. As cell phone radiation is no where as close to high speed particles from space. At any instance of time, there is multiple EM bands that is traversing our body. Radio transmissions from different technologies. Very hard to trace cell phone towards their interactivity with the cellular functions.

Of course, protein will fold to a different order structure when heat is applied.

[Niels Bohr 72]

If you really need that article, I can have the library submit a request for it. Takes about 2 days to get it. Probably Harvard or Tufts Medicine will have that journal. I can't find it here.

[HAL 9000 96]

Electromagnetic Fields is the specialty of physicist and electrical engineers. Don't know if in medicine you guys study EMF fields, energy distribution, propagation, Laplace, Gaussian, vectors analysis.

Cell phone radiation can't possibly interact with the protein structures. As cell phone radiation is no where as close to high speed particles from space. At any instance of time, there is multiple EM bands that is traversing our body. Radio transmissions from different technologies. Very hard to trace cell phone towards their interactivity with the cellular functions.

Of course, protein will fold to a different order structure when heat is applied.

Any energy particle will cause a disturbance in the Force.

No, seriously... any kind of energy displacement can and does affect the molecular resonance of proteins as well as the metabolic byproducts of cellular physiology. As for how cell phone radiation can do such a thing, its still in debate. If it were not for the biophysical properties of each and every protein and nitrogenated base (DNA) that's been meticulously studied thus far, there would not be any discernible results.

To cite one example- I've done extensive electrophysiology on several kinds of cells before. Mostly neurons. By clamping current or voltage one can study not just the electrical properties of these cells under different pharmacological conditions, but even the molecular mechanisms inside them using specific techniques that marry biology, chemistry, and physics. One has to shield the entire 'rig' one uses in order to prevent even 60-cycle noise (from ceiling lights, for example) from creating too high a background reading on the cells themselves. Imagine something with a higher operational frequency.

[IR5FORMUMSIE 850]

Just checked. We do NOT have it on our library subscription registry. Sorry.

My accounts are down but I don't think that I've ever heard of that publication. It is more in the realm of radiation oncology and those guyz iz nucking futs. I'm not too up on heat shock protein remodeling, I thought that it was primarily the quaternary structures of the hsp that change or do the tertiary structures also change and this causes the quaternary structure to also change. Sorry, I'm tired I can't think stright right now and I haven't looked at this stuff in a while.

I wonder if this makes anyone else think about the safety of cell phones.

Maximum stimulus detected! LOL

Not sure about the journal. If they had published in Wiley's publishing group or at least a journal that Pubmed Central could mirror for free then hey... we'd likely not have this thread.

So I actually was at a mitochondrion talk last week that showed some awesome Hsp60 staining at the cell level. It was a cancer talk, but it dealt more with metabolic changes in a tumor line after knocking out another gene.

So as to the Hsp's themselves- most of them stay in quaternary formation (unless you're dealing with a cellular disorder that actually denatures them down in level to 3ry or *gasp* lower) because they tend to respect subcellular compartmentalization really strictly. Hence why you have mitochondrial Hsp's and cytosolic ones. Obviously once something like Hsp60 is translated its targeted to mitochondria since it may have once been in the mitochondrial genome... but that changed with evolution. So it had to travel back to the mitochondrion. Once membrane translocation occurs into the mitochondrial matrix then it resumes its mature 4ry structure.

I guess the entire point of heat therapy at certain stages of mitochondrial dysfunction would involve activating these Hsp60s to target heat-affected proteins (da daaa... usually those that are already damaged or associated with reactive oxygen species) for degradatory measures without having the entire mitochondrion lose its membrane potential and thusly, caspase activation.

I wonder though what kind of feasable strategy a therapist could use to heat the brain to such a point where, say, a striatal tumor could be attacked via such a route without overactivating other Hsp proteins to push entire cells... too far. Its not like most neurons can revert back to pre-cell cycle arrest.

I guess I tend to think more in the clinical sense (that is when I can think at all ) of how something might be done. Certainly the idea that you might be able to correct via splicing and the appropriate plasmid etc. seems easy enough but it's not as easy as it sounds. Some form of a specific dedicated cytosolic transport mechanism, whereby hsp60 only gets shuttled into the cytosol of the affected striatum cells and then into the mitochondrion and remains active is something someone is probably looking into even as we speak. There is a great of research into finding a neoplasmic specific vector but in the meantime we're still frying cells. I sometimes daydream if there is a way to introduce inert cells that act as blast shields around the aberrant cell to allow more aggressive therapies without worrying about the problems associated with the loss of healthy tissue and cells. You'll have to excuse my ignorance on this matter, I never made it past the second grade and I learned all this stuff from a Bazooka Joe comic.

[HAL 9000 96]

Just checked. We do NOT have it on our library subscription registry. Sorry.

My accounts are down but I don't think that I've ever heard of that publication. It is more in the realm of radiation oncology and those guyz iz nucking futs. I'm not too up on heat shock protein remodeling, I thought that it was primarily the quaternary structures of the hsp that change or do the tertiary structures also change and this causes the quaternary structure to also change. Sorry, I'm tired I can't think stright right now and I haven't looked at this stuff in a while.

I wonder if this makes anyone else think about the safety of cell phones.

Maximum stimulus detected! LOL

Not sure about the journal. If they had published in Wiley's publishing group or at least a journal that Pubmed Central could mirror for free then hey... we'd likely not have this thread.

So I actually was at a mitochondrion talk last week that showed some awesome Hsp60 staining at the cell level. It was a cancer talk, but it dealt more with metabolic changes in a tumor line after knocking out another gene.

So as to the Hsp's themselves- most of them stay in quaternary formation (unless you're dealing with a cellular disorder that actually denatures them down in level to 3ry or *gasp* lower) because they tend to respect subcellular compartmentalization really strictly. Hence why you have mitochondrial Hsp's and cytosolic ones. Obviously once something like Hsp60 is translated its targeted to mitochondria since it may have once been in the mitochondrial genome... but that changed with evolution. So it had to travel back to the mitochondrion. Once membrane translocation occurs into the mitochondrial matrix then it resumes its mature 4ry structure.

I guess the entire point of heat therapy at certain stages of mitochondrial dysfunction would involve activating these Hsp60s to target heat-affected proteins (da daaa... usually those that are already damaged or associated with reactive oxygen species) for degradatory measures without having the entire mitochondrion lose its membrane potential and thusly, caspase activation.

I wonder though what kind of feasable strategy a therapist could use to heat the brain to such a point where, say, a striatal tumor could be attacked via such a route without overactivating other Hsp proteins to push entire cells... too far. Its not like most neurons can revert back to pre-cell cycle arrest.

I guess I tend to think more in the clinical sense (that is when I can think at all ) of how something might be done. Certainly the idea that you might be able to correct via splicing and the appropriate plasmid etc. seems easy enough but it's not as easy as it sounds. Some form of a specific dedicated cytosolic transport mechanism, whereby hsp60 only gets shuttled into the cytosol of the affected striatum cells and then into the mitochondrion and remains active is something someone is probably looking into even as we speak. There is a great of research into finding a neoplasmic specific vector but in the meantime we're still frying cells. I sometimes daydream if there is a way to introduce inert cells that act as blast shields around the aberrant cell to allow more aggressive therapies without worrying about the problems associated with the loss of healthy tissue and cells. You'll have to excuse my ignorance on this matter, I never made it past the second grade and I learned all this stuff from a Bazooka Joe comic.

That's cool... I got all my stuff out of a Cracker Jack Box.

Problem is that you need Hsp60 in the mitochondrion to chaperone ROS-affected proteins from causing loss of mitochondrion membrane potential. Remember the electron transport chain... and now imagine build up of all those electron acceptors at the end of it... gotta keep that machine well oiled and running otherwise you lose the factory.

Although something like 15-20% of Hsp60 IS cytosolic.

In the cytoplasm you have plenty of other Hsp (110 is good for temperature extremes, 90 is the big daddy, 70 gets help from 40 in keeping protein from folding all crazy, etc)... of course not counting on ER Hsp doing their things in protein folding.

Man I miss this stuff from cell bio.

[scandal 951]

Just checked. We do NOT have it on our library subscription registry. Sorry.

My accounts are down but I don't think that I've ever heard of that publication. It is more in the realm of radiation oncology and those guyz iz nucking futs. I'm not too up on heat shock protein remodeling, I thought that it was primarily the quaternary structures of the hsp that change or do the tertiary structures also change and this causes the quaternary structure to also change. Sorry, I'm tired I can't think stright right now and I haven't looked at this stuff in a while.

I wonder if this makes anyone else think about the safety of cell phones.

Maximum stimulus detected! LOL

Not sure about the journal. If they had published in Wiley's publishing group or at least a journal that Pubmed Central could mirror for free then hey... we'd likely not have this thread.

So I actually was at a mitochondrion talk last week that showed some awesome Hsp60 staining at the cell level. It was a cancer talk, but it dealt more with metabolic changes in a tumor line after knocking out another gene.

So as to the Hsp's themselves- most of them stay in quaternary formation (unless you're dealing with a cellular disorder that actually denatures them down in level to 3ry or *gasp* lower) because they tend to respect subcellular compartmentalization really strictly. Hence why you have mitochondrial Hsp's and cytosolic ones. Obviously once something like Hsp60 is translated its targeted to mitochondria since it may have once been in the mitochondrial genome... but that changed with evolution. So it had to travel back to the mitochondrion. Once membrane translocation occurs into the mitochondrial matrix then it resumes its mature 4ry structure.

I guess the entire point of heat therapy at certain stages of mitochondrial dysfunction would involve activating these Hsp60s to target heat-affected proteins (da daaa... usually those that are already damaged or associated with reactive oxygen species) for degradatory measures without having the entire mitochondrion lose its membrane potential and thusly, caspase activation.

I wonder though what kind of feasable strategy a therapist could use to heat the brain to such a point where, say, a striatal tumor could be attacked via such a route without overactivating other Hsp proteins to push entire cells... too far. Its not like most neurons can revert back to pre-cell cycle arrest.

I guess I tend to think more in the clinical sense (that is when I can think at all ) of how something might be done. Certainly the idea that you might be able to correct via splicing and the appropriate plasmid etc. seems easy enough but it's not as easy as it sounds. Some form of a specific dedicated cytosolic transport mechanism, whereby hsp60 only gets shuttled into the cytosol of the affected striatum cells and then into the mitochondrion and remains active is something someone is probably looking into even as we speak. There is a great of research into finding a neoplasmic specific vector but in the meantime we're still frying cells. I sometimes daydream if there is a way to introduce inert cells that act as blast shields around the aberrant cell to allow more aggressive therapies without worrying about the problems associated with the loss of healthy tissue and cells. You'll have to excuse my ignorance on this matter, I never made it past the second grade and I learned all this stuff from a Bazooka Joe comic.

That's cool... I got all my stuff out of a Cracker Jack Box.

Problem is that you need Hsp60 in the mitochondrion to chaperone ROS-affected proteins from causing loss of mitochondrion membrane potential. Remember the electron transport chain... and now imagine build up of all those electron acceptors at the end of it... gotta keep that machine well oiled and running otherwise you lose the factory.

Although something like 15-20% of Hsp60 IS cytosolic.

In the cytoplasm you have plenty of other Hsp (110 is good for temperature extremes, 90 is the big daddy, 70 gets help from 40 in keeping protein from folding all crazy, etc)... of course not counting on ER Hsp doing their things in protein folding.

Man I miss this stuff from cell bio.

In other news... man was spotted biting a dog today:

[HAL 9000 96]

[IR5FORMUMSIE 850]

Electromagnetic Fields is the specialty of physicist and electrical engineers. Don't know if in medicine you guys study EMF fields, energy distribution, propagation, Laplace, Gaussian, vectors analysis.

Cell phone radiation can't possibly interact with the protein structures. As cell phone radiation is no where as close to high speed particles from space. At any instance of time, there is multiple EM bands that is traversing our body. Radio transmissions from different technologies. Very hard to trace cell phone towards their interactivity with the cellular functions.

Of course, protein will fold to a different order structure when heat is applied.

Any energy particle will cause a disturbance in the Force.

No, seriously... any kind of energy displacement can and does affect the molecular resonance of proteins as well as the metabolic byproducts of cellular physiology. As for how cell phone radiation can do such a thing, its still in debate. If it were not for the biophysical properties of each and every protein and nitrogenated base (DNA) that's been meticulously studied thus far, there would not be any discernible results.

To cite one example- I've done extensive electrophysiology on several kinds of cells before. Mostly neurons. By clamping current or voltage one can study not just the electrical properties of these cells under different pharmacological conditions, but even the molecular mechanisms inside them using specific techniques that marry biology, chemistry, and physics. One has to shield the entire 'rig' one uses in order to prevent even 60-cycle noise (from ceiling lights, for example) from creating too high a background reading on the cells themselves. Imagine something with a higher operational frequency.

I'm guessing for this fun stuff you get to play with squiddy. Seriously we can easily look at testicular cancer among police officer and see a link (not necessarily a strong one) since cops used to stick radar guns down their pants like guns. The big problem is that cancer or any other neoplastic disorder isn't caused by only one thing. Just looking at a neuron or any other cell from a basic standpoint, energy will excite electrons and as the electrons start moving further from nucleus, atomic radius starts increasing. In the case of a proteins with their massive size and the need to have things tightly packed, conformational change is bad, things need to line up precisely. If even one atom is out of place there's going to be a problem if everything isn't in the lowest possible energy state. Now energy in any form gets introduced, it has to go somewhere and this affect the proteins. Think of an earthquake, what happens to the streets, the buildings, etc. Microwaves denature proteins and some cell phone frequencies are in the microwave range, mind you portable phones also operate at similar frequencies but then the question becomes what level of exposure (power levels come into play) is too much.

[IR5FORMUMSIE 850]

Just checked. We do NOT have it on our library subscription registry. Sorry.

My accounts are down but I don't think that I've ever heard of that publication. It is more in the realm of radiation oncology and those guyz iz nucking futs. I'm not too up on heat shock protein remodeling, I thought that it was primarily the quaternary structures of the hsp that change or do the tertiary structures also change and this causes the quaternary structure to also change. Sorry, I'm tired I can't think stright right now and I haven't looked at this stuff in a while.

I wonder if this makes anyone else think about the safety of cell phones.

Maximum stimulus detected! LOL

Not sure about the journal. If they had published in Wiley's publishing group or at least a journal that Pubmed Central could mirror for free then hey... we'd likely not have this thread.

So I actually was at a mitochondrion talk last week that showed some awesome Hsp60 staining at the cell level. It was a cancer talk, but it dealt more with metabolic changes in a tumor line after knocking out another gene.

So as to the Hsp's themselves- most of them stay in quaternary formation (unless you're dealing with a cellular disorder that actually denatures them down in level to 3ry or *gasp* lower) because they tend to respect subcellular compartmentalization really strictly. Hence why you have mitochondrial Hsp's and cytosolic ones. Obviously once something like Hsp60 is translated its targeted to mitochondria since it may have once been in the mitochondrial genome... but that changed with evolution. So it had to travel back to the mitochondrion. Once membrane translocation occurs into the mitochondrial matrix then it resumes its mature 4ry structure.

I guess the entire point of heat therapy at certain stages of mitochondrial dysfunction would involve activating these Hsp60s to target heat-affected proteins (da daaa... usually those that are already damaged or associated with reactive oxygen species) for degradatory measures without having the entire mitochondrion lose its membrane potential and thusly, caspase activation.

I wonder though what kind of feasable strategy a therapist could use to heat the brain to such a point where, say, a striatal tumor could be attacked via such a route without overactivating other Hsp proteins to push entire cells... too far. Its not like most neurons can revert back to pre-cell cycle arrest.

I guess I tend to think more in the clinical sense (that is when I can think at all ) of how something might be done. Certainly the idea that you might be able to correct via splicing and the appropriate plasmid etc. seems easy enough but it's not as easy as it sounds. Some form of a specific dedicated cytosolic transport mechanism, whereby hsp60 only gets shuttled into the cytosol of the affected striatum cells and then into the mitochondrion and remains active is something someone is probably looking into even as we speak. There is a great of research into finding a neoplasmic specific vector but in the meantime we're still frying cells. I sometimes daydream if there is a way to introduce inert cells that act as blast shields around the aberrant cell to allow more aggressive therapies without worrying about the problems associated with the loss of healthy tissue and cells. You'll have to excuse my ignorance on this matter, I never made it past the second grade and I learned all this stuff from a Bazooka Joe comic.

That's cool... I got all my stuff out of a Cracker Jack Box.

Problem is that you need Hsp60 in the mitochondrion to chaperone ROS-affected proteins from causing loss of mitochondrion membrane potential. Remember the electron transport chain... and now imagine build up of all those electron acceptors at the end of it... gotta keep that machine well oiled and running otherwise you lose the factory.

Although something like 15-20% of Hsp60 IS cytosolic.

In the cytoplasm you have plenty of other Hsp (110 is good for temperature extremes, 90 is the big daddy, 70 gets help from 40 in keeping protein from folding all crazy, etc)... of course not counting on ER Hsp doing their things in protein folding.

Man I miss this stuff from cell bio.

Like I said I haven't looked at this stuff in a long time. Had a friend who was really into the ETC, not me though. I was just thinking that since we can't really place hsp60 in the mitochondrion directly we could figure out a way to shuttle it in like L-carnitine into cell. The size and volume would be a problem but I would think there would be a way to do it. Great, now I'll pull out my damn notes and start thinking about this stuff all weekend. Oh, look there's a man biting a dog.

I always knew that Ozzy hated those mutts.

[HAL 9000 96]

Electromagnetic Fields is the specialty of physicist and electrical engineers. Don't know if in medicine you guys study EMF fields, energy distribution, propagation, Laplace, Gaussian, vectors analysis.

Cell phone radiation can't possibly interact with the protein structures. As cell phone radiation is no where as close to high speed particles from space. At any instance of time, there is multiple EM bands that is traversing our body. Radio transmissions from different technologies. Very hard to trace cell phone towards their interactivity with the cellular functions.

Of course, protein will fold to a different order structure when heat is applied.

Any energy particle will cause a disturbance in the Force.

No, seriously... any kind of energy displacement can and does affect the molecular resonance of proteins as well as the metabolic byproducts of cellular physiology. As for how cell phone radiation can do such a thing, its still in debate. If it were not for the biophysical properties of each and every protein and nitrogenated base (DNA) that's been meticulously studied thus far, there would not be any discernible results.

To cite one example- I've done extensive electrophysiology on several kinds of cells before. Mostly neurons. By clamping current or voltage one can study not just the electrical properties of these cells under different pharmacological conditions, but even the molecular mechanisms inside them using specific techniques that marry biology, chemistry, and physics. One has to shield the entire 'rig' one uses in order to prevent even 60-cycle noise (from ceiling lights, for example) from creating too high a background reading on the cells themselves. Imagine something with a higher operational frequency.

I'm guessing for this fun stuff you get to play with squiddy. Seriously we can easily look at testicular cancer among police officer and see a link (not necessarily a strong one) since cops used to stick radar guns down their pants like guns. The big problem is that cancer or any other neoplastic disorder isn't caused by only one thing. Just looking at a neuron or any other cell from a basic standpoint, energy will excite electrons and as the electrons start moving further from nucleus, atomic radius starts increasing. In the case of a proteins with their massive size and the need to have things tightly packed, conformational change is bad, things need to line up precisely. If even one atom is out of place there's going to be a problem if everything isn't in the lowest possible energy state. Now energy in any form gets introduced, it has to go somewhere and this affect the proteins. Think of an earthquake, what happens to the streets, the buildings, etc. Microwaves denature proteins and some cell phone frequencies are in the microwave range, mind you portable phones also operate at similar frequencies but then the question becomes what level of exposure (power levels come into play) is too much.

Poor cops!

Dude... very true. One atom... no biggie there. I just try to think of the geometry of those interactions every time the cell phone rads vs neurons not larger than 30 microns in diameter... and all that is inside of them. Nasty? Maybe.

I was lucky to learn on crayfish motor neurons. But the research had to be mammalian so I had to homogenize embryonic mouse hypocampus quite a lot for those experiments.

[HAL 9000 96]

Look for GroEL (Hsp60) + cell distribution. I think that physiologically speaking, whatever Hsp60 could be doing cytosolically can be upregulated using other pathways that might not need so much manipulation from a clinical perspective.

[IR5FORMUMSIE 850]

Electromagnetic Fields is the specialty of physicist and electrical engineers. Don't know if in medicine you guys study EMF fields, energy distribution, propagation, Laplace, Gaussian, vectors analysis.

Cell phone radiation can't possibly interact with the protein structures. As cell phone radiation is no where as close to high speed particles from space. At any instance of time, there is multiple EM bands that is traversing our body. Radio transmissions from different technologies. Very hard to trace cell phone towards their interactivity with the cellular functions.

Of course, protein will fold to a different order structure when heat is applied.

Any energy particle will cause a disturbance in the Force.

No, seriously... any kind of energy displacement can and does affect the molecular resonance of proteins as well as the metabolic byproducts of cellular physiology. As for how cell phone radiation can do such a thing, its still in debate. If it were not for the biophysical properties of each and every protein and nitrogenated base (DNA) that's been meticulously studied thus far, there would not be any discernible results.

To cite one example- I've done extensive electrophysiology on several kinds of cells before. Mostly neurons. By clamping current or voltage one can study not just the electrical properties of these cells under different pharmacological conditions, but even the molecular mechanisms inside them using specific techniques that marry biology, chemistry, and physics. One has to shield the entire 'rig' one uses in order to prevent even 60-cycle noise (from ceiling lights, for example) from creating too high a background reading on the cells themselves. Imagine something with a higher operational frequency.

I'm guessing for this fun stuff you get to play with squiddy. Seriously we can easily look at testicular cancer among police officer and see a link (not necessarily a strong one) since cops used to stick radar guns down their pants like guns. The big problem is that cancer or any other neoplastic disorder isn't caused by only one thing. Just looking at a neuron or any other cell from a basic standpoint, energy will excite electrons and as the electrons start moving further from nucleus, atomic radius starts increasing. In the case of a proteins with their massive size and the need to have things tightly packed, conformational change is bad, things need to line up precisely. If even one atom is out of place there's going to be a problem if everything isn't in the lowest possible energy state. Now energy in any form gets introduced, it has to go somewhere and this affect the proteins. Think of an earthquake, what happens to the streets, the buildings, etc. Microwaves denature proteins and some cell phone frequencies are in the microwave range, mind you portable phones also operate at similar frequencies but then the question becomes what level of exposure (power levels come into play) is too much.

Poor cops!

Dude... very true. One atom... no biggie there. I just try to think of the geometry of those interactions every time the cell phone rads vs neurons not larger than 30 microns in diameter... and all that is inside of them. Nasty? Maybe.

I was lucky to learn on crayfish motor neurons. But the research had to be mammalian so I had to homogenize embryonic mouse hypocampus quite a lot for those experiments.

Big bro' was into that Neurophysiology #######. He got his MSc and was getting set to go the PhD route when he got fed up and went to Med School. He did all that crayfish stuff, but he got monkeys and football players (aren't they the same ) to experiment on.

I don't use a cell phone for this very reason. It may sound silly but it kinda scares me.

[HAL 9000 96]

Oh man

There is a reason I am more into cell bio apllications at the moment... all that neurophys was driving me nuts. I got sick of referring to the Axon Guide as my go-to book.