discarded embryos to generate blood for transfusions

[Amby 490]

Researchers in the UK plan to make what's being hailed as an unlimited supply of blood for transfusions using discarded stem cells found in human embryos, according to news reports.

They'll test embryos discarded from in vitro fertilization (IVF) treatments to find those with embryonic stem cells that will make O-negative blood, which is the one type that can be transfused into anyone without being rejected.

An adult has about 4–6 liters of blood (which transports oxygen through the body), white blood cells to fight infection, and platelets that clot to heal wounds. Many patients died of transfusions before 1901, when the Austrian Karl Landsteiner discovered the human blood types. Landsteiner found that antibodies against donor blood can cause deadly clumping.

Still, supplies of blood available for life-saving transfusions are limited. Local and regional pleas for blood by the Red Cross, owing to critically low levels, have become routine in the past decade. There's more to it all than just giving blood. There are a host of tests that must be run on donor blood to make sure it is free of infection. And blood has a limited shelf life. Blood stored for 29 days or more (nearly 2 weeks less than the current standard for blood storage) is more likely to cause infection in transfusion patients, a study last year found.

Embryonic stem cells have the ability to become all the cells of the body. The idea is that harnessing their power would allow infinite production of what'd being termed "synthetic" blood that would be free of any infections that sometime plague blood supplies.

"In principle, we could provide an unlimited supply of blood in this way," said team member Marc Turner, director of the Scottish National Blood Transfusion Service.

This is no backwater laboratory effort. It's also being supported by NHS Blood and Transplant and the Wellcome Trust, the world's biggest medical research charity, according to The Independent.

In 2004, researchers at the University of Minnesota published research explaining the conditions under which blood cell development occurs from embryonic stem cells. But embryonic stem cell research has been somewhat stifled in the United States owing to restrictions on federal funding that were lifted earlier this month by the Obama administration. There may be time to catch up to the UK effort.

"We should have proof of principle in the next few years, but a realistic treatment is probably five to 10 years away," Turner said.

http://www.livescience.com/health/090323-embryo-blood.html