Dramatic diabetes find

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CHICAGO - A new study gives the strongest evidence yet that obesity surgery can cure diabetes.

Patients who had surgery to reduce the size of their stomachs were five times more likely to see their diabetes disappear over the next two years than were patients who had standard diabetes care, according to Australian researchers.

Most of the surgery patients were able to stop taking diabetes drugs and achieve normal blood tests.

"It's the best therapy for diabetes that we have today, and it's very low risk," said the study's lead author, Dr. John Dixon of Monash University Medical School in Melbourne, Australia.

The patients had stomach band surgery, a procedure more common in Australia than in the United States, where gastric bypass surgery, or stomach stapling, predominates.

Gastric bypass is even more effective against diabetes, achieving remission in a matter of days or a month, said Dr. David Cummings, who wrote an accompanying editorial in the journal but was not involved in the study.

"We have traditionally considered diabetes to be a chronic, progressive disease," said Cummings of the University of Washington in Seattle. "But these operations really do represent a realistic hope for curing most patients."

Diabetes experts who read the study said surgery should be considered for some obese patients, but more research is needed to see how long results last and which patients benefit most. Surgery risks should be weighed against diabetes drug side effects and the long-term risks of diabetes itself, they said.

Experts generally agree that weight-loss surgery would never be appropriate for diabetics who are not obese, and current federal guidelines restrict the surgery to obese people.

The diabetes benefits of weight-loss surgery were known, but the Australian study in Wednesday's Journal of the American Medical Association is the first of its kind to compare diabetes in patients randomly assigned to surgery or standard care. Scientists consider randomized studies to yield the highest-quality evidence.

The study involved 55 patients, so experts will be looking for results of larger experiments under way.

"Few studies really qualify as being a landmark study. This one is," said Dr. Philip Schauer, who was not involved in the Australian research but leads a Cleveland Clinic study that is recruiting 150 obese people with diabetes to compare two types of surgery and standard medical care.

"This opens an entirely new way of thinking about diabetes."

Obesity is a major risk factor for diabetes, and researchers are furiously pursuing reasons for the link as rates for both climb. What's known is that excess fat can cause the body's normal response to insulin to go haywire. Researchers are investigating insulin-regulating hormones released by fat and the role of fatty acids in the blood.

In the Australian study, all the patients were obese and had been diagnosed with type 2 diabetes during the past two years. Their average age was 47. Half the patients underwent a type of surgery called laparoscopic gastric banding, where an adjustable silicone cuff is installed around the upper stomach, limiting how much a person can eat.

Both groups lost weight over two years; the surgery patients lost 46 pounds on average, while the standard-care patients lost an average of 3 pounds.

Blood tests showed diabetes remission in 22 of the 29 surgery patients after two years. In the standard-care group, only four of the 26 patients achieved that goal. The patients who lost the most weight were the most likely to eliminate their diabetes.

Both patient groups learned about low-fat, high-fiber diets and were encouraged to exercise. Both groups could meet with a health professional every six weeks for two years.

The death rate for stomach band surgery, which can cost $17,000 to $20,000, is about 1 in 1,000. There were only minor complications in the study. Stomach stapling has a 2 percent death rate and costs $20,000 to $30,000.

In the United States, surgeons perform more than 100,000 obesity surgeries each year.

The American Diabetes Association is interested in the findings. The group revises its recommendations each fall, taking new research into account.

"There is a growing body of evidence that bariatric surgery is an effective tool for managing diabetes," said Dr. John Buse of the University of North Carolina School of Medicine in Chapel Hill, the association's president for medicine and science.

"It's just a question of how effective is it, for what spectrum of patients, over what period of time and at what cost? Not all those questions have been answered yet."

Medical devices used in the study were provided by the manufacturers, but the companies had no say over the study's design or its findings, Dixon said.

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On the Net:

JAMA: http://jama.ama-assn.org

[HAL 9000 96]

Low fat, low sugar diets in pre-diabetic patients tend to cause a decrease in pancreatic Islet cell mass and reduce the overproduction of insulin that helps in many patients prevent or delay the onset of Type 2 Diabetes. Islet cells (Beta cells in particular) produce insulin at "normal" levels until challenged by increased glucose levels to produce more insulin and simultaneously "poisoned" by free form fatty acids (from high fat diets). The end result is swollen Beta cells that try to pump out more insulin to compensate for the decreasing numbers of Beta cells. Then, its full blown Type 2 Diabetes.

Right now some researchers are trying frantically to identify endogenous stem cells that can step in and replace lost Beta cells in recovering patients. These stem cells would be there already and just need to be identified and turned on.

It is possible that this surgery, by combining a decreased dietary intake and a leaner diet, facilitate over the long term a better recovery phase for sick Beta cells.

[Hilarious Clinton 452]

Type 2 diabetes is reversible. I've said that before but naysayers on VJ said it wasn't possible.

[one...two...tree 2,762]

Low fat, low sugar diets in pre-diabetic patients tend to cause a decrease in pancreatic Islet cell mass and reduce the overproduction of insulin that helps in many patients prevent or delay the onset of Type 2 Diabetes. Islet cells (Beta cells in particular) produce insulin at "normal" levels until challenged by increased glucose levels to produce more insulin and simultaneously "poisoned" by free form fatty acids (from high fat diets). The end result is swollen Beta cells that try to pump out more insulin to compensate for the decreasing numbers of Beta cells. Then, its full blown Type 2 Diabetes.

Right now some researchers are trying frantically to identify endogenous stem cells that can step in and replace lost Beta cells in recovering patients. These stem cells would be there already and just need to be identified and turned on.

It is possible that this surgery, by combining a decreased dietary intake and a leaner diet, facilitate over the long term a better recovery phase for sick Beta cells.

That makes more sense. Stomach bands just don't sound like a good idea. My grandmother had most of her stomach removed (this was in the 60's) because of ulcers, but we believe in the long run, it really had an adverse affect on her overall health.

[HAL 9000 96]

Type 2 diabetes is reversible. I've said that before but naysayers on VJ said it wasn't possible.

For the most part, it is, even though from a patient's point of care, is very difficult. What we can't say is that its curable at this point.

[HAL 9000 96]

Low fat, low sugar diets in pre-diabetic patients tend to cause a decrease in pancreatic Islet cell mass and reduce the overproduction of insulin that helps in many patients prevent or delay the onset of Type 2 Diabetes. Islet cells (Beta cells in particular) produce insulin at "normal" levels until challenged by increased glucose levels to produce more insulin and simultaneously "poisoned" by free form fatty acids (from high fat diets). The end result is swollen Beta cells that try to pump out more insulin to compensate for the decreasing numbers of Beta cells. Then, its full blown Type 2 Diabetes.

Right now some researchers are trying frantically to identify endogenous stem cells that can step in and replace lost Beta cells in recovering patients. These stem cells would be there already and just need to be identified and turned on.

It is possible that this surgery, by combining a decreased dietary intake and a leaner diet, facilitate over the long term a better recovery phase for sick Beta cells.

That makes more sense. Stomach bands just don't sound like a good idea. My grandmother had most of her stomach removed (this was in the 60's) because of ulcers, but we believe in the long run, it really had an adverse affect on her overall health.

That's the thing about T2DM... it has a range of flexibility that allows treatments that combat several different potential causes that over time, combine to become pathological. By addressing the root causes we can prevent the effects. Funny how so many different facets of existence can be paralleled to biological principles.